Dose-Response (May 2019)

The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries

  • Tijana Kovacevic,
  • Branislava Miljkovic,
  • Momir Mikov,
  • Svjetlana Stojisavljevic Satara,
  • Sasa Dragic,
  • Danica Momcicevic,
  • Pedja Kovacevic

DOI
https://doi.org/10.1177/1559325819850419
Journal volume & issue
Vol. 17

Abstract

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Purpose: To determine whether severe hypoalbuminemia (25 mg/L; 23.04 [19.14] vs 13.28 [11.28], P = .01). In the group of patients who received the vancomycin loading dose of 2 g, C min was significantly higher in patients with severe hypoalbuminemia compared to the patients with nonsevere hypoalbuminemia (34.52 [25.93] vs 15.37 [10.48], P = .04). Conclusion: In critically ill septic patients with severe hypoalbuminemia, there is a high probability that the loading dose of vancomycin is not necessary since it is associated with potentially toxic vancomycin C min , while in the patients with nonsevere hypoalbuminemia the loading dose may be necessary to achieving therapeutic C min .