Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy

Swayam Prakash Srivastava; Han Zhou; Ocean Setia; Bing Liu; Keizo Kanasaki; Daisuke Koya; Alan Dardik; Carlos Fernandez-Hernando; Julie Goodwin

doi:10.1038/s41467-021-22617-y

Nature Communications (Apr 2021)

Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy

Swayam Prakash Srivastava,
Han Zhou,
Ocean Setia,
Bing Liu,
Keizo Kanasaki,
Daisuke Koya,
Alan Dardik,
Carlos Fernandez-Hernando,
Julie Goodwin

Affiliations

Swayam Prakash Srivastava: Department of Pediatrics, Yale University School of Medicine New Haven
Han Zhou: Department of Pediatrics, Yale University School of Medicine New Haven
Ocean Setia: Vascular Biology and Therapeutics Program, Yale University School of Medicine New Haven
Bing Liu: Department of Pediatrics, Yale University School of Medicine New Haven
Keizo Kanasaki: Department of Diabetology and Endocrinology, Kanazawa Medical University
Daisuke Koya: Department of Diabetology and Endocrinology, Kanazawa Medical University
Alan Dardik: Vascular Biology and Therapeutics Program, Yale University School of Medicine New Haven
Carlos Fernandez-Hernando: Vascular Biology and Therapeutics Program, Yale University School of Medicine New Haven
Julie Goodwin: Department of Pediatrics, Yale University School of Medicine New Haven

DOI: https://doi.org/10.1038/s41467-021-22617-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of fatty acid oxidation in diabetic kidneys.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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