Nature Communications (Feb 2022)

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor

  • Beatriz Herguedas,
  • Bianka K. Kohegyi,
  • Jan-Niklas Dohrke,
  • Jake F. Watson,
  • Danyang Zhang,
  • Hinze Ho,
  • Saher A. Shaikh,
  • Remigijus Lape,
  • James M. Krieger,
  • Ingo H. Greger

DOI
https://doi.org/10.1038/s41467-022-28404-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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AMPA glutamate receptors, mediate the majority of excitatory signaling in the brain. Here the authors show how the auxiliary subunit TARP-γ8 shapes gating kinetics, ion conductance and rectification properties of the heteromeric GluA1/2 AMPA receptor.