Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: a case report and literature review
Keita Miyake,
Takashi Hara,
Etsuko Oshima,
Kiyohiro Kawada,
Hideki Ishizu,
Yuko Yamauchi,
Katsuya Satoh,
Tetsuyuki Kitamoto,
Shintaro Takenoshita,
Seishi Terada,
Norihito Yamada
Affiliations
Keita Miyake
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Takashi Hara
Department of Psychiatry, Hayashi Hospital
Etsuko Oshima
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kiyohiro Kawada
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Hideki Ishizu
Department of Psychiatry, Zikei Hospital
Yuko Yamauchi
Department of Psychiatry, Zikei Hospital
Katsuya Satoh
Department of Locomotive Rehabilitation Sciences, Nagasaki University Graduate School of Medicine
Tetsuyuki Kitamoto
Department of Neurological Science, Tohoku University Graduate School of Medicine
Shintaro Takenoshita
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Seishi Terada
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Norihito Yamada
Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Abstract Background Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.
