Nature Communications (Aug 2019)

Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D

  • Shumeng Jiang,
  • Cheng Lyu,
  • Peng Zhao,
  • Wenjing Li,
  • Wenyu Kong,
  • Chenyu Huang,
  • Guy M. Genin,
  • Yanan Du

DOI
https://doi.org/10.1038/s41467-019-11397-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Cellular responses to mechanical stimulation have emerged as an important area of research. Here, the authors use cryoprotectant to control the pore size and mechanical properties of porous scaffolds without changing the scaffold composition to allow for the study of cellular mechano-responsiveness in 3D.