Nature Communications (May 2021)
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
- Jun Deng,
- Qian Chen,
- Zhian Chen,
- Kaili Liang,
- Xin Gao,
- Xiaohui Wang,
- Fadzai V. Makota,
- Hong Sheng Ong,
- Yanmin Wan,
- Kaiming Luo,
- Dongcheng Gong,
- Xiang Yu,
- Sarina Camuglia,
- Qunxiong Zeng,
- Tao Zhou,
- Feng Xue,
- Jing He,
- Yunbo Wei,
- Fan Xiao,
- Jianyang Ma,
- Danika L. Hill,
- Wim Pierson,
- Thi H. O. Nguyen,
- Haibo Zhou,
- Yan Wang,
- Wei Shen,
- Lingyun Sun,
- Zhanguo Li,
- Qiang Xia,
- Kun Qian,
- Lilin Ye,
- Steven Rockman,
- Michelle A. Linterman,
- Katherine Kedzierska,
- Nan Shen,
- Liwei Lu,
- Di Yu
Affiliations
- Jun Deng
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Qian Chen
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Zhian Chen
- Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University
- Kaili Liang
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Xin Gao
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Xiaohui Wang
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Fadzai V. Makota
- Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University
- Hong Sheng Ong
- Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University
- Yanmin Wan
- Department of Infectious Diseases, Huashan Hospital, Fudan University
- Kaiming Luo
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Dongcheng Gong
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Xiang Yu
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Sarina Camuglia
- Seqirus
- Qunxiong Zeng
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Tao Zhou
- Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Feng Xue
- Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Jing He
- Department of Rheumatology and Immunology, Peking University People’s Hospital
- Yunbo Wei
- Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences)
- Fan Xiao
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Jianyang Ma
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Danika L. Hill
- Lymphocyte Signaling and Development, Babraham Institute
- Wim Pierson
- Lymphocyte Signaling and Development, Babraham Institute
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Haibo Zhou
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Yan Wang
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Wei Shen
- Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Lingyun Sun
- Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School
- Zhanguo Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital
- Qiang Xia
- Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Kun Qian
- School of Biomedical Engineering, Shanghai Jiao Tong University
- Lilin Ye
- Institute of Immunology, Third Military Medical University
- Steven Rockman
- Seqirus
- Michelle A. Linterman
- Lymphocyte Signaling and Development, Babraham Institute
- Katherine Kedzierska
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Nan Shen
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Liwei Lu
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Di Yu
- China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23220-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes TFH differentiation and that low leptin levels can impair TFH response to vaccines and virus protection in mice.
