Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning
Jiawei Han,
Ruixue Wang,
Minmin Wang,
Zhihua Yu,
Liang Zhu,
Jianmin Zhang,
Junming Zhu,
Shaomin Zhang,
Wang Xi,
Hemmings Wu
Affiliations
Jiawei Han
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China; Clinical Research Center for Neurological Disease of Zhejiang Province, Hangzhou 310058, China
Ruixue Wang
Department of Neurosurgery, Third Affiliated Hospital, Naval Medical University, Shanghai 200438, China; Qiushi Academy for Advanced Studies, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China
Minmin Wang
Qiushi Academy for Advanced Studies, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China
Zhihua Yu
Department of Critical Care Medicine, Hangzhou Third People’s Hospital, Hangzhou 310058, China
Liang Zhu
Interdisciplinary Institute of Neuroscience and Technology (ZIINT), College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; Interdisciplinary Institute of Neuroscience and Technology (ZIINT), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310020, China
Jianmin Zhang
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China; Clinical Research Center for Neurological Disease of Zhejiang Province, Hangzhou 310058, China
Junming Zhu
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China; Clinical Research Center for Neurological Disease of Zhejiang Province, Hangzhou 310058, China
Shaomin Zhang
Qiushi Academy for Advanced Studies, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China; Corresponding author
Wang Xi
Interdisciplinary Institute of Neuroscience and Technology (ZIINT), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310020, China; MOE Frontier Science Center for Brain Research and Brain Machine Integration, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; Corresponding author
Hemmings Wu
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China; Clinical Research Center for Neurological Disease of Zhejiang Province, Hangzhou 310058, China; Corresponding author
Summary: Understanding the adaptability of the motor cortex in response to bilateral motor tasks is crucial for advancing our knowledge of neural plasticity and motor learning. Here we aim to investigate the dynamic lateralization of contralateral-projecting corticospinal neurons (cpCSNs) during such tasks. Utilizing in vivo two-photon calcium imaging, we observe cpCSNs in mice performing a “left-right” lever-press task. Our findings reveal heterogeneous populational dynamics in cpCSNs: a marked decrease in activity during ipsilateral motor learning, in contrast to maintained activity during contralateral motor learning. Notably, individual cpCSNs show dynamic shifts in engagement with ipsilateral and contralateral movements, displaying an evolving pattern of activation over successive days. It suggests that cpCSNs exhibit adaptive changes in activation patterns in response to ipsilateral and contralateral movements, highlighting a flexible reorganization during motor learning This reconfiguration underscores the dynamic nature of cortical lateralization in motor learning and offers insights for neuromotor rehabilitation.
