Primary Epstein–Barr virus infection and probable parvovirus B19 reactivation resulting in fulminant hepatitis and fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis

Matthias Karrasch; Jörg Felber; Peter M. Keller; Christine Kletta; Renate Egerer; Jürgen Bohnert; Beate Hermann; Wolfgang Pfister; Bernhard Theis; Iver Petersen; Andreas Stallmach; Michael Baier

doi:10.1016/j.ijid.2014.08.003

International Journal of Infectious Diseases (Nov 2014)

Primary Epstein–Barr virus infection and probable parvovirus B19 reactivation resulting in fulminant hepatitis and fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis

Matthias Karrasch,
Jörg Felber,
Peter M. Keller,
Christine Kletta,
Renate Egerer,
Jürgen Bohnert,
Beate Hermann,
Wolfgang Pfister,
Bernhard Theis,
Iver Petersen,
Andreas Stallmach,
Michael Baier

Affiliations

Matthias Karrasch: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany
Jörg Felber: Department of Internal Medicine IV, University Hospital, Friedrich-Schiller-University, Jena, Germany
Peter M. Keller: Department of Internal Medicine IV, University Hospital, Friedrich-Schiller-University, Jena, Germany
Christine Kletta: Emergency Room, University Hospital, Friedrich-Schiller-University, Jena, Germany
Renate Egerer: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany
Jürgen Bohnert: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany
Beate Hermann: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany
Wolfgang Pfister: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany
Bernhard Theis: Institute of Pathology, University Hospital, Friedrich-Schiller-University, Jena, Germany
Iver Petersen: Institute of Pathology, University Hospital, Friedrich-Schiller-University, Jena, Germany
Andreas Stallmach: Department of Internal Medicine IV, University Hospital, Friedrich-Schiller-University, Jena, Germany
Michael Baier: Institute of Medical Microbiology, University Hospital, Friedrich-Schiller-University, Erlanger Allee 101, 07743 Jena, Germany

DOI: https://doi.org/10.1016/j.ijid.2014.08.003
Journal volume & issue: Vol. 28, no. C
pp. 143 – 146

Abstract

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A case of primary Epstein–Barr virus (EBV) infection/parvovirus B19 reactivation fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis (HLH) is presented. Despite two coinciding viral infections, massive splenomegaly, and fulminant hepatitis, the patient had a good clinical outcome, probably due to an early onset form of HLH with normal leukocyte count, normal natural killer (NK) cell function, and a lack of hemophagocytosis.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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