Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population

Abstract

Abstract Background The IL-33/ST2 pathway plays a crucial role in the development of essential hypertension (EH). This study aimed to investigate the relationship between EH and genetic variations in this pathway in the Chinese Han population. Methods A total of 1,151 EH patients and 1,135 healthy controls were included in the study. Sixteen single nucleotide polymorphisms (SNPs) in the interleukin-33 (IL-33) and interleukin-1receptor associated protein (IL-1RAcP) genes were genotyped using the Sequenom MassArray and TaqMan assays. Genotype and allele frequencies were compared between the EH patients and controls using logistic regression analysis. Results The rs16865597 SNP in the IL-1RAcP gene was found to be associated with the risk of EH. Specifically, the presence of the C allele of rs16865597 was negatively correlated with EH susceptibility in both the additive model (P = 0.014, OR = 0.75, 95% CI = 0.59–0.94) and the recessive model (P = 0.011, OR = 0.72, 95% CI = 0.56–0.93). Additionally, rs16865597 was linked to a reduced risk of EH in specific subgroups, including males (OR add = 0.73, 95% CI = 0.56–0.94, P = 0.015), nonsmokers (OR add = 0.72, 95% CI = 0.54–0.96, P = 0.023), nondrinkers (OR add = 0.70, 95% CI = 0.53–0.93, P = 0.013), and individuals with low BMI (OR add = 0.69, 95% CI = 0.51–0.92, P = 0.013). Moreover, the C genotype of rs16865597 was strongly associated with higher interleukin-10 levels in vivo. Conclusion The rs16865597 SNP is significantly associated with a reduced risk of EH in the Chinese Han population, potentially due to its role in immune regulation.

Keywords

• Essential hypertension
• Interleukin-33
• interleukin-1receptor associated protein
• Genetic polymorphisms
• rs16865597