METABOLISM

Abstract

According to the World Health Organization experts, the prevalence of diabetes is ahead of the most pessimistic forecasts and has already acquired the character of non-infectious epidemic in the world. Furthermore, today there is a tendency not only to the increase in the incidence of type 2 diabetes, but to the prevalence of comorbid conditions, including osteoporosis and osteopenia. In turn, in recent decades, osteoporosis is one of the most widespread and socially significant diseases, in all countries without exception its frequency in recent decades has been steadily increasing particularly among postmenopausal women. At the same time, a special state of bone metabolism in patients with type 2 diabetes is marked. The paper presents the study results of the content of the markers of bone metabolism in postmenopausal women with type 2 diabetes. Twenty-eight women, 15 of them with type 2 diabetes and 13 - in the control group were examined. The levels of ionized calcium, 25-OH vitamin D, osteocalcin, N-terminal propeptide of type 1 procollagen C-terminal telopeptides of type I collagen were determined. We also estimated the average daily calcium intake in women with type 2 diabetes. A substantial reduction in markers of bone metabolism, reflecting fixation processes, due to lower markers characterizing osteoresorption in patients with type 2 diabetes relative to the control group was determined. The findings raise the question of further studies of the mechanisms of formation of bone metabolism disorders in conditions of hyperglycemia.

Keywords

• frax
• diabetes mellitus
• osteoporosis
• insufficiency/deficiency of vitamin d
• frax