Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy

Jana Krystofova Mike; Yasmine White; Rachel S. Hutchings; Christian Vento; Janica Ha; Ariana Iranmahboub; Hadiya Manzoor; Anya Gunewardena; Cheryl Cheah; Aijun Wang; Brian D. Goudy; Satyan Lakshminrusimha; Janel Long-Boyle; Jeffrey R. Fineman; Donna M. Ferriero; Emin Maltepe

doi:10.3390/children10111728

Children (Oct 2023)

Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy

Jana Krystofova Mike,
Yasmine White,
Rachel S. Hutchings,
Christian Vento,
Janica Ha,
Ariana Iranmahboub,
Hadiya Manzoor,
Anya Gunewardena,
Cheryl Cheah,
Aijun Wang,
Brian D. Goudy,
Satyan Lakshminrusimha,
Janel Long-Boyle,
Jeffrey R. Fineman,
Donna M. Ferriero,
Emin Maltepe

Affiliations

Jana Krystofova Mike: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Yasmine White: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Rachel S. Hutchings: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Christian Vento: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Janica Ha: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Ariana Iranmahboub: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Hadiya Manzoor: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Anya Gunewardena: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Cheryl Cheah: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Aijun Wang: Department of Biomedical Engineering, University of California Davis, Davis, CA 95817, USA
Brian D. Goudy: Department of Pediatrics, University of California Davis, Davis, CA 95817, USA
Satyan Lakshminrusimha: Department of Pediatrics, University of California Davis, Davis, CA 95817, USA
Janel Long-Boyle: School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, USA
Jeffrey R. Fineman: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Donna M. Ferriero: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA
Emin Maltepe: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA

DOI: https://doi.org/10.3390/children10111728
Journal volume & issue: Vol. 10, no. 11
p. 1728

Abstract

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Originally approved by the U.S. Food and Drug Administration (FDA) for its antihistamine properties, clemastine can also promote white matter integrity and has shown promise in the treatment of demyelinating diseases such as multiple sclerosis. Here, we conducted an in-depth analysis of the feasibility, safety, and neuroprotective efficacy of clemastine administration in near-term lambs (n = 25, 141–143 days) following a global ischemic insult induced via an umbilical cord occlusion (UCO) model. Lambs were randomly assigned to receive clemastine or placebo postnatally, and outcomes were assessed over a six-day period. Clemastine administration was well tolerated. While treated lambs demonstrated improvements in inflammatory scores, their neurodevelopmental outcomes were unchanged.

Published in Children

ISSN: 2227-9067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://www.mdpi.com/journal/children

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