Фармакокинетика и Фармакодинамика (Jan 2019)

Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats

  • V. P. Zherdev,
  • G. B. Kolyvanov,
  • A. A. Litvin,
  • P. O. Bochkov,
  • O. G. Gribakina,
  • R. V. Shevchenko,
  • A. V. Tarasyuk,
  • T. A. Gudasheva

DOI
https://doi.org/10.24411/2587-7836-2019-10038
Journal volume & issue
Vol. 0, no. 1
pp. 37 – 43

Abstract

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Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h. The GSB-106 tissue availability in high-vascularized organs (liver, kidney, spleen) was over then skeletal muscle. In brain (target-organ) that parameter was 0.05. In the 24-hour urine the parent compound was not detected and in the feces were determined of 0.0001 % GSB-106 after oral administration in dose 150 mg/kg. The absolute bioavailability of GSB-106 was 5.6 %.

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