SFTSV infection is associated with transient overproliferation of monoclonal lambda-type plasma cells

Chuansong Quan; Qinghua Liu; Lijuan Yu; Chunjing Li; Kaixiao Nie; Guoyong Ding; Hong Zhou; Xinli Wang; Wenwen Sun; Huiliang Wang; Maokui Yue; Li Wei; Wenjun Zheng; Qiang Lyu; Weijia Xing; Zhenjie Zhang; Michael J. Carr; Hong Zhang; Weifeng Shi

iScience (Jun 2023)

SFTSV infection is associated with transient overproliferation of monoclonal lambda-type plasma cells

Chuansong Quan,
Qinghua Liu,
Lijuan Yu,
Chunjing Li,
Kaixiao Nie,
Guoyong Ding,
Hong Zhou,
Xinli Wang,
Wenwen Sun,
Huiliang Wang,
Maokui Yue,
Li Wei,
Wenjun Zheng,
Qiang Lyu,
Weijia Xing,
Zhenjie Zhang,
Michael J. Carr,
Hong Zhang,
Weifeng Shi

Affiliations

Chuansong Quan: Department of Infectious Disease, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China; Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Qinghua Liu: Department of Clinical Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Lijuan Yu: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Chunjing Li: Department of Hematology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Kaixiao Nie: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Guoyong Ding: School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250117, China
Hong Zhou: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Xinli Wang: Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Wenwen Sun: Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Huiliang Wang: Department of Infectious Disease, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Maokui Yue: Department of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Li Wei: Department of Respiratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
Wenjun Zheng: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Qiang Lyu: School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250117, China
Weijia Xing: School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250117, China
Zhenjie Zhang: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
Michael J. Carr: National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin 4, Ireland; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, N20 W10 Kita-ku, Sapporo 001-0020, Japan
Hong Zhang: Department of Infectious Disease, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China; Department of Hematology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China; Corresponding author
Weifeng Shi: Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250117, China; Corresponding author

Journal volume & issue: Vol. 26, no. 6
p. 106799

Abstract

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Summary: The impairment of antibody-mediated immunity is a major factor associated with fatal cases of severe fever with thrombocytopenia syndrome (SFTS). By collating the clinical diagnosis reports of 30 SFTS cases, we discovered the overproliferation of monoclonal plasma cells (MCP cells, CD38+cLambda+cKappa−) in bone marrow, which has only been reported previously in multiple myeloma. The ratio of CD38+cLambda+ versus CD38+cKappa+ in SFTS cases with MCP cells was significantly higher than that in normal cases. MCP cells presented transient expression in the bone marrow, which was distinctly different from multiple myeloma. Moreover, the SFTS patients with MCP cells had higher clinical severity. Further, the overproliferation of MCP cells was also observed in SFTS virus (SFTSV)-infected mice with lethal infectious doses. Together, SFTSV infection induces transient overproliferation of monoclonal lambda-type plasma cells, which have important implications for the study of SFTSV pathogenesis, prognosis, and the rational development of therapeutics.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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