Developmental changes in neonatal hemodynamics during tactile stimulation using whole-head functional near-infrared spectroscopy
Yutaka Fuchino,
Ikuko Kato,
Yinmon Htun,
Yuji Takano,
Yukihiko Konishi,
Kosuke Koyano,
Shinji Nakamura,
Naoki Tanaka,
Takashi Kusaka,
Yukuo Konishi
Affiliations
Yutaka Fuchino
Language Sciences, Department of Human Sciences, Graduate School of Humanities, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; Research Center for Language, Brain and Genetics, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; Corresponding author at: Language Sciences, Department of Human Sciences, Graduate School of Humanities, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan.
Ikuko Kato
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Yinmon Htun
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Yuji Takano
Department of Psychology, Faculty of Human Environment, University of Human Environments, Okazaki, Japan
Yukihiko Konishi
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Kosuke Koyano
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Shinji Nakamura
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Naoki Tanaka
Research Institute of Industrial Technology, Toyo University, Kawagoe, Saitama, Japan
Takashi Kusaka
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Yukuo Konishi
Center for Baby Science, Doshisha University, Kizugawa, Kyoto, Japan
Neural-activity-associated hemodynamic changes have been used to noninvasively measure brain function in the early developmental stages. However, the temporal changes in their hemodynamics are not always consistent with adults. Studies have not evaluated developmental changes for a long period using the same stimuli; therefore, this study examined the normalized relative changes in oxygenated hemoglobin (Δ[oxy-Hb]) in full-term infants and compared them with neonates up to 10 months of age during the administration of tactile vibration stimuli to their limbs using whole-head functional near-infrared spectroscopy. The time to peak of normalized Δ[oxy-Hb] was not affected by age. The amplitude of normalized Δ[oxy-Hb] showed an effect of age in broader areas, including sensorimotor-related but excluding supplementary motor area; the amplitude of normalized Δ[oxy-Hb] decreased the most in the 1–2-month-old group and later increased with development. We hypothesized that these results may reflect developmental changes in neural activity, vasculature, and blood oxygenation.
