Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Michael D. Kessler; Laura Yerges-Armstrong; Margaret A. Taub; Amol C. Shetty; Kristin Maloney; Linda Jo Bone Jeng; Ingo Ruczinski; Albert M. Levin; L. Keoki Williams; Terri H. Beaty; Rasika A. Mathias; Kathleen C. Barnes; Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA); Timothy D. O’Connor

doi:10.1038/ncomms12521

Nature Communications (Oct 2016)

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Michael D. Kessler,
Laura Yerges-Armstrong,
Margaret A. Taub,
Amol C. Shetty,
Kristin Maloney,
Linda Jo Bone Jeng,
Ingo Ruczinski,
Albert M. Levin,
L. Keoki Williams,
Terri H. Beaty,
Rasika A. Mathias,
Kathleen C. Barnes,
Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA),
Timothy D. O’Connor

Affiliations

Michael D. Kessler: Institute for Genome Sciences, University of Maryland School of Medicine
Laura Yerges-Armstrong: Department of Medicine, University of Maryland School of Medicine
Margaret A. Taub: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University
Amol C. Shetty: Institute for Genome Sciences, University of Maryland School of Medicine
Kristin Maloney: Program in Personalized and Genomic Medicine, University of Maryland School of Medicine
Linda Jo Bone Jeng: Program in Personalized and Genomic Medicine, University of Maryland School of Medicine
Ingo Ruczinski: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University
Albert M. Levin: Department of Public Health Sciences, Henry Ford Health System
L. Keoki Williams: Center for Health Policy & Health Services Research, Henry Ford Health System
Terri H. Beaty: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University
Rasika A. Mathias: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University
Kathleen C. Barnes: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University
Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA)
Timothy D. O’Connor: Institute for Genome Sciences, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/ncomms12521
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

Read online

Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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