Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Bragina Elena Yu.; Goncharova Irina A.; Garaeva Anna F.; Nemerov Evgeniy V.; Babovskaya Anastasija A.; Karpov Andrey B.; Semenova Yulia V.; Zhalsanova Irina Z.; Gomboeva Densema E.; Saik Olga V.; Zolotareva Olga I.; Ivanisenko Vladimir A.; Dosenko Victor E.; Hofestaedt Ralf; Freidin Maxim B.

doi:10.1515/jib-2018-0052

Journal of Integrative Bioinformatics (Dec 2018)

Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Bragina Elena Yu.,
Goncharova Irina A.,
Garaeva Anna F.,
Nemerov Evgeniy V.,
Babovskaya Anastasija A.,
Karpov Andrey B.,
Semenova Yulia V.,
Zhalsanova Irina Z.,
Gomboeva Densema E.,
Saik Olga V.,
Zolotareva Olga I.,
Ivanisenko Vladimir A.,
Dosenko Victor E.,
Hofestaedt Ralf,
Freidin Maxim B.

Affiliations

Bragina Elena Yu.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Goncharova Irina A.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Garaeva Anna F.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Nemerov Evgeniy V.: Siberian State Medical University, Tomsk, Russia
Babovskaya Anastasija A.: Siberian State Medical University, Tomsk, Russia
Karpov Andrey B.: Seversk Biophysical Research Centre of the Federal Medico-Biological Agency, Seversk, Russia
Semenova Yulia V.: Seversk Clinical Hospital, Siberian Federal Research and Clinical Centre of the Federal Medico-Biological Agency, Seversk, Russia
Zhalsanova Irina Z.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Gomboeva Densema E.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
Saik Olga V.: The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Zolotareva Olga I.: Bielefeld University, Bioinformatics/Medical Informatics Department, Bielefeld, Germany
Ivanisenko Vladimir A.: The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Dosenko Victor E.: Bogomoletz Institute of Physiology, National Academy of Science, Kiev, Ukraine
Hofestaedt Ralf: Bielefeld University, Bioinformatics/Medical Informatics Department, Bielefeld, Germany
Freidin Maxim B.: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia

DOI: https://doi.org/10.1515/jib-2018-0052
Journal volume & issue: Vol. 15, no. 4
pp. 1055 – 68

Abstract

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Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated.

Published in Journal of Integrative Bioinformatics

ISSN: 1613-4516 (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.degruyter.com/view/j/jib

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