Nature Communications (Mar 2022)
Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity
- Chen Yang,
- Yuzheng Hu,
- Aleksandr D. Talishinsky,
- Christian T. Potter,
- Coleman B. Calva,
- Leslie A. Ramsey,
- Andrew J. Kesner,
- Reuben F. Don,
- Sue Junn,
- Aaron Tan,
- Anne F. Pierce,
- Céline Nicolas,
- Yosuke Arima,
- Seung-Chan Lee,
- Conghui Su,
- Jensine M. Coudriet,
- Carlos A. Mejia-Aponte,
- Dong V. Wang,
- Hanbing Lu,
- Yihong Yang,
- Satoshi Ikemoto
Affiliations
- Chen Yang
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Yuzheng Hu
- Department of Psychology and Behavioral Sciences, Zhejiang University
- Aleksandr D. Talishinsky
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Christian T. Potter
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Coleman B. Calva
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Leslie A. Ramsey
- Ex Vivo Electrophysiology Core, National Institute on Drug Abuse, National Institutes of Health
- Andrew J. Kesner
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Reuben F. Don
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Sue Junn
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Aaron Tan
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Anne F. Pierce
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Céline Nicolas
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Yosuke Arima
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Seung-Chan Lee
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Conghui Su
- Department of Psychology and Behavioral Sciences, Zhejiang University
- Jensine M. Coudriet
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Carlos A. Mejia-Aponte
- Histology Core, National Institute on Drug Abuse, National Institutes of Health
- Dong V. Wang
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- Hanbing Lu
- MR Imaging and Spectroscopy Section, National Institute on Drug Abuse, National Institutes of Health
- Yihong Yang
- MR Imaging and Spectroscopy Section, National Institute on Drug Abuse, National Institutes of Health
- Satoshi Ikemoto
- Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-28892-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
The prefrontal cortex is involved in goal-directed behaviour. Here the authors show that medial prefrontal cortex activates goal-directed motivation and dopamine neurons via a feedback loop with the anteromedial thalamus.
