The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series
Wenlin Wu,
Jie Hong,
Yanping Ran,
Wenxiao Wu,
Haixia Zhu,
Chi Hou,
Yuanyuan Gao,
Yulin Tang,
Yinting Liao,
Wen-Xiong Chen,
Xiaojing Li
Affiliations
Wenlin Wu
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Jie Hong
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Yanping Ran
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Wenxiao Wu
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Haixia Zhu
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Chi Hou
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Yuanyuan Gao
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Yulin Tang
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Yinting Liao
Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Wen-Xiong Chen
Corresponding author. Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City No.9, Jinsui Road, Tianhe District, Guangzhou City, 510623, Guangdong Province, China.; Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Xiaojing Li
Corresponding author. Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, No.9, Jinsui Road, Tianhe District, Guangzhou City, 510623, Guangdong Province, China.; Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China
Ofatumumab (OFA) is an anti-CD20 antibody. We assessed the therapeutic potential of OFA in five pediatric anti-NMDAR encephalitis patients who showed poor responses to the first-line immunotherapy. OFA treatment showed clinical improvement including alleviation of clinical symptoms and mRS decrease accompanied by anti-NMDAR antibody turning negative in 3 patients and decline in 2 patients. And all patients achieved B cell depletion after OFA treatment. During follow-up, all patients’ symptoms were stable. OFA treatment is safe and effective, easy to administer, and favorable for pediatric anti-NMDAE encephalitis patients who are refractory to the first-line immunotherapy.
