KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia

Ashraf Abdullah Saad; Ismail Beshlawi; Mathew Zachariah; Yasser Wali

doi:10.5001/omj.2019.99

Oman Medical Journal (Nov 2019)

KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia

Ashraf Abdullah Saad,
Ismail Beshlawi,
Mathew Zachariah,
Yasser Wali

Affiliations

Ashraf Abdullah Saad: Pediatric Hematology, Oncology and HSCT Unit, Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
Ismail Beshlawi: Pediatric Hematology, Oncology and HSCT Unit, Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
Mathew Zachariah: Pediatric Hematology, Oncology and HSCT Unit, Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
Yasser Wali: Pediatric Hematology, Oncology and HSCT Unit, Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman

DOI: https://doi.org/10.5001/omj.2019.99
Journal volume & issue: Vol. 34, no. 6
pp. 553 – 555

Abstract

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We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.

Published in Oman Medical Journal

ISSN: 1999-768X (Print); 2070-5204 (Online)
Publisher: Oman Medical Specialty Board
Country of publisher: Oman
LCC subjects: Medicine
Website: http://www.omjournal.org

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