Imine as a linchpin approach for meta-C–H functionalization

Sukdev Bag; Sadhan Jana; Sukumar Pradhan; Suman Bhowmick; Nupur Goswami; Soumya Kumar Sinha; Debabrata Maiti

doi:10.1038/s41467-021-21633-2

Nature Communications (Mar 2021)

Imine as a linchpin approach for meta-C–H functionalization

Sukdev Bag,
Sadhan Jana,
Sukumar Pradhan,
Suman Bhowmick,
Nupur Goswami,
Soumya Kumar Sinha,
Debabrata Maiti

Affiliations

Sukdev Bag: Department of Chemistry, Indian Institute of Technology Bombay
Sadhan Jana: Department of Chemistry, Indian Institute of Technology Bombay
Sukumar Pradhan: Department of Chemistry, Indian Institute of Technology Bombay
Suman Bhowmick: Department of Chemistry, Indian Institute of Technology Bombay
Nupur Goswami: Department of Chemistry, Indian Institute of Technology Bombay
Soumya Kumar Sinha: Department of Chemistry, Indian Institute of Technology Bombay
Debabrata Maiti: Department of Chemistry, Indian Institute of Technology Bombay

DOI: https://doi.org/10.1038/s41467-021-21633-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Site-selective C–H functionalization still faces some challenges, such as the introduction and removal of an appropriate directing group. Here, the authors introduce a temporary directing group for selective meta-C–H functionalization of 2-arylbenzaldehydes via reversible imine formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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