Pediatric Health, Medicine and Therapeutics (Jun 2025)
Isolated Diffuse Splenic Hemangiomatosis Arising in an Adolescent: A Rare Case Report and Literature Review
Abstract
Zhuping Chen,1 Dongdong Zhang1,2 1Department of Hematology, Postgraduate Union Training Base of Xiangyang No.1 People’s Hospital, School of Medicine, Wuhan University of Science and Technology, Xiangyang, Hubei, 441000, People’s Republic of China; 2Department of Oncology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, People’s Republic of ChinaCorrespondence: Dongdong Zhang, Department of Oncology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Jiefang Road No. 15, Xiangyang, Hubei, 441000, People’s Republic of China, Tel +8615072278600, Email [email protected]: Diffuse splenic hemangiomatosis (DSH) is an extremely rare benign vascular disorder characterized by the proliferation of multiple blood vessels within the spleen. It is even rarer in pediatric and adolescent patients, with only a few cases reported in medical literature, which was performed as scientific literature review.Case Presentation: We observed a 14-year-old male who presented with intermittent abdominal discomfort and slight splenomegaly. Laboratory tests revealed no abnormalities. Computed tomography (CT) revealed diffuse splenomegaly with round or oval low-density lesions, suggestive of hemangiomatosis or lymphoma. Magnetic resonance imaging (MRI) revealed multiple lesions with slightly prolonged T1 and T2 signals. A CT-guided percutaneous biopsy of a splenic lesion was performed to address splenomegaly and diagnostic uncertainty. Histopathological examination confirmed diffuse splenic hemangiomatosis with lymphocytic infiltration.Conclusion: A rare case of DSH in a childhood was presented. This case underscores the importance of integrating imaging and histopathology for an accurate diagnosis. While the condition is typically benign, tissue biopsy remains the definitive diagnostic method when malignancy cannot be excluded.Keywords: diffuse splenic hemangiomatosis, lymphoma, splenomegaly, tissue biopsy
