Nature Communications (Dec 2017)
Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis
- Xiaomin Yao,
- Chenhong Zhang,
- Yue Xing,
- Guang Xue,
- Qianpeng Zhang,
- Fengwei Pan,
- Guojun Wu,
- Yingxin Hu,
- Qiuhong Guo,
- Ailing Lu,
- Xiaoming Zhang,
- Rongbin Zhou,
- Zhigang Tian,
- Benhua Zeng,
- Hong Wei,
- Warren Strober,
- Liping Zhao,
- Guangxun Meng
Affiliations
- Xiaomin Yao
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Chenhong Zhang
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Yue Xing
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Guang Xue
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Qianpeng Zhang
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Fengwei Pan
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Guojun Wu
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Yingxin Hu
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Qiuhong Guo
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Ailing Lu
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Xiaoming Zhang
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Rongbin Zhou
- Department of Immunology, School of Life Sciences, University of Science and Technology of China
- Zhigang Tian
- Department of Immunology, School of Life Sciences, University of Science and Technology of China
- Benhua Zeng
- Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University
- Hong Wei
- Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University
- Warren Strober
- Mucosal Immunity Section, Laboratory for Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Liping Zhao
- State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Guangxun Meng
- Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-017-01917-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Inflammasomes are involved in gut homeostasis and inflammatory pathologies. The authors show that a hyperactive NLRP3 inflammasome maintains gut homeostasis through remodelling of the gut microbiota and induction of regulatory T cells.
