One-carbon metabolic enzymes are regulated during cell division and make distinct contributions to the metabolome and cell cycle progression in <i>Saccharomyces cerevisiae</i>

Abstract

AbstractEnzymes of one-carbon (1C) metabolism play pivotal roles in proliferating cells. They are involved in the metabolism of amino acids, nucleotides, and lipids and the supply of all cellular methylations. However, there is limited information about how these enzymes are regulated during cell division and how cell cycle kinetics are affected in several loss-of-function mutants of 1C metabolism. Here, we report that the levels of the S. cerevisiaecho2Δcho2Δ