Frontiers in Endocrinology (Aug 2023)

Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control

  • Eduardo García,
  • Eduardo García,
  • Eduardo García,
  • Eduardo García,
  • Pedro Gil,
  • Inka Miñambres,
  • Aleyda Benitez-Amaro,
  • Aleyda Benitez-Amaro,
  • Aleyda Benitez-Amaro,
  • Claudia Rodríguez,
  • Lene Claudi,
  • Lene Claudi,
  • Lene Claudi,
  • Josep Julve,
  • Josep Julve,
  • Josep Julve,
  • Josep Julve,
  • Sonia Benitez,
  • Sonia Benitez,
  • Sonia Benitez,
  • Jose Luís Sánchez-Quesada,
  • Jose Luís Sánchez-Quesada,
  • Jose Luís Sánchez-Quesada,
  • Jose Rives,
  • Jose Rives,
  • Xavier Garcia-Moll,
  • David Vilades,
  • David Vilades,
  • David Vilades,
  • Antonio Perez,
  • Antonio Perez,
  • Vicenta Llorente-Cortes,
  • Vicenta Llorente-Cortes,
  • Vicenta Llorente-Cortes,
  • Vicenta Llorente-Cortes

DOI
https://doi.org/10.3389/fendo.2023.1236487
Journal volume & issue
Vol. 14

Abstract

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BackgroundLow-density lipoprotein receptor-related protein 1 (LRP1) negatively modulates circulating atrial natriuretic peptide (ANP) levels. Both molecules are involved in the regulation of cardiometabolism.ObjectivesTo evaluate soluble LRP1 (sLRP1) and ANP levels in people with newly diagnosed type 2 diabetes mellitus (T2DM) and determine the effects of metabolic optimization.MethodsThis single-center longitudinal observational study recruited patients with newly diagnosed T2DM (n = 29, HbA1c > 8.5%), and 12 healthy control, age- and sex-matched volunteers. sLRP1 and ANP levels were measured by immunoassays at T2DM onset and at one year after optimization of glycemic control (HbA1c ≤ 6.5%).ResultsT2DM had higher sLRP1 levels than the control group (p = 0.014) and lower ANP levels (p =0.002). At 12 months, 23 T2DM patients reached the target of HbA1c ≤ 6.5%. These patients significantly reduced sLRP1 and increased ANP levels. Patients who did not achieve HbA1c < 6.5% failed to normalize sLRP1 and ANP levels. There was an inverse correlation in the changes in sLRP1 and ANP (p = 0.031). The extent of sLRP1 changes over 12 months of metabolic control positively correlated with those of total cholesterol, LDL cholesterol, TG, TG/HDLc, and apolipoprotein B.ConclusionsNewly diagnosed T2DM patients have an increased sLRP1/ANP ratio, and increased sLRP1 and decreased ANP levels are normalized in the T2DM patients that reached an strict glycemic and metabolic control. sLRP1/ANP ratio could be a reliable marker of cardiometabolic function.

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