Oral pyogenic granuloma: An unusual presentation in tongue – Case report and comprehensive review

Abstract

Pyogenic granuloma (PG) is a reactive, hyperplastic lesion of the skin and mucosa in response to chronic irritation. It clinically presents as sessile or pedunculated growth, most commonly in the gingiva. The clinical and histopathological spectrum of PG depends on the phase of the lesion. Healing lesions are pinkish white compared to reddish lesions in the established phase. Long-standing lesions show features of fibrosis and calcification. We report a case of PG extra gingival in location, on the left lateral surface of tongue in a 45-year-old male with an insight into etiopathogenesis, clinical presentation, histopathological, molecular, and immunohistochemical features. Novel concept of isolation of stem cells from pathological tissues such as PG might help future research in regenerative dentistry.

Keywords

• pyogenic granuloma
• regenerative dentistry
• stem cell
• tongue