Research Progress on Melanoma-associated Antigen Gene-really Interesting New Gene (MAGE-RING) Ligases

Abstract

Melanoma-associated antigen gene(MAGE) is regarded as a popular target for cancer markers and immunotherapy. It was found that MAGE combined with E3-RING ubiquitin ligase to form MAGE-RING ligase complex(MRLs). MRLs are regulatory factors for ubiquitination to regulate the activity of the ligase, the specificity of the substrate and the subcellular localization. The structure, activation mechanism and transcription function of MRLs are reviewed in this article.

Keywords

• melanoma-associated antigen gene
• mage-ring ligases
• ubiquitination
• ubiquitin-ligase