Nature Communications (Apr 2018)

Molecular basis for the folding of β-helical autotransporter passenger domains

  • Xiaojun Yuan,
  • Matthew D. Johnson,
  • Jing Zhang,
  • Alvin W. Lo,
  • Mark A. Schembri,
  • Lakshmi C. Wijeyewickrema,
  • Robert N. Pike,
  • Gerard H. M. Huysmans,
  • Ian R. Henderson,
  • Denisse L. Leyton

DOI
https://doi.org/10.1038/s41467-018-03593-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Autotransporter passenger domains are presented on or released from the bacterial surface upon translocation through an outer membrane β-barrel anchor. Here the authors study the two E. coli autotransporters Pet and EspP and propose that the β-barrel anchor acts as a vector to nucleate the folding of the passenger domain.