Advances in Chirality Sensing with Macrocyclic Molecules
Xiaotong Liang,
Wenting Liang,
Pengyue Jin,
Hongtao Wang,
Wanhua Wu,
Cheng Yang
Affiliations
Xiaotong Liang
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Architecture and Environment, Sichuan University, Chengdu 610064, China
Wenting Liang
Department of Chemistry, Institute of Environmental Science, Shanxi University, Taiyuan 030006, China
Pengyue Jin
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Architecture and Environment, Sichuan University, Chengdu 610064, China
Hongtao Wang
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Architecture and Environment, Sichuan University, Chengdu 610064, China
Wanhua Wu
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Architecture and Environment, Sichuan University, Chengdu 610064, China
Cheng Yang
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Architecture and Environment, Sichuan University, Chengdu 610064, China
The construction of chemical sensors that can distinguish molecular chirality has attracted increasing attention in recent years due to the significance of chiral organic molecules and the importance of detecting their absolute configuration and chiroptical purity. The supramolecular chirality sensing strategy has shown promising potential due to its advantages of high throughput, sensitivity, and fast chirality detection. This review focuses on chirality sensors based on macrocyclic compounds. Macrocyclic chirality sensors usually have inherent complexing ability towards certain chiral guests, which combined with the signal output components, could offer many unique advantages/properties compared to traditional chiral sensors. Chirality sensing based on macrocyclic sensors has shown rapid progress in recent years. This review summarizes recent advances in chirality sensing based on both achiral and chiral macrocyclic compounds, especially newly emerged macrocyclic molecules.