Nature Communications (Apr 2019)
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
- Anne Dirkse,
- Anna Golebiewska,
- Thomas Buder,
- Petr V. Nazarov,
- Arnaud Muller,
- Suresh Poovathingal,
- Nicolaas H. C. Brons,
- Sonia Leite,
- Nicolas Sauvageot,
- Dzjemma Sarkisjan,
- Mathieu Seyfrid,
- Sabrina Fritah,
- Daniel Stieber,
- Alessandro Michelucci,
- Frank Hertel,
- Christel Herold-Mende,
- Francisco Azuaje,
- Alexander Skupin,
- Rolf Bjerkvig,
- Andreas Deutsch,
- Anja Voss-Böhme,
- Simone P. Niclou
Affiliations
- Anne Dirkse
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Anna Golebiewska
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Thomas Buder
- Zentrum für Informationsdienste und Hochleistungsrechnen, Technische Universität Dresden
- Petr V. Nazarov
- Proteome and Genome Research Unit, Department of Oncology, Luxembourg Institute of Health
- Arnaud Muller
- Proteome and Genome Research Unit, Department of Oncology, Luxembourg Institute of Health
- Suresh Poovathingal
- Luxembourg Centre for Systems Biomedicine, University of Luxembourg
- Nicolaas H. C. Brons
- National Cytometry Platform, Luxembourg Institute of Health
- Sonia Leite
- Centre of Competence for Methodology and Statistics, Luxembourg Institute of Health
- Nicolas Sauvageot
- Centre of Competence for Methodology and Statistics, Luxembourg Institute of Health
- Dzjemma Sarkisjan
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Mathieu Seyfrid
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Sabrina Fritah
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Daniel Stieber
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Alessandro Michelucci
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Frank Hertel
- Department of Neurosurgery, Centre Hospitalier Luxembourg
- Christel Herold-Mende
- Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg
- Francisco Azuaje
- Proteome and Genome Research Unit, Department of Oncology, Luxembourg Institute of Health
- Alexander Skupin
- Luxembourg Centre for Systems Biomedicine, University of Luxembourg
- Rolf Bjerkvig
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Andreas Deutsch
- Zentrum für Informationsdienste und Hochleistungsrechnen, Technische Universität Dresden
- Anja Voss-Böhme
- Zentrum für Informationsdienste und Hochleistungsrechnen, Technische Universität Dresden
- Simone P. Niclou
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- DOI
- https://doi.org/10.1038/s41467-019-09853-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions induced by the microenvironment.
