Korean Journal of Pediatrics (Dec 2014)

BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation

  • Seung Beom Han,
  • Bin Cho,
  • Jin Han Kang

DOI
https://doi.org/10.3345/kjp.2014.57.12.514
Journal volume & issue
Vol. 57, no. 12
pp. 514 – 519

Abstract

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Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis, pediatricians outside the hemato-oncology and nephrology specialties tend to be unfamiliar with hemorrhagic cystitis and the BK virus. Moreover, no standard guidelines for the early diagnosis and treatment of BK virus-associated hemorrhagic cystitis after stem cell transplantation have been established. Here, we briefly introduce poststem cell transplantation BK virus-associated hemorrhagic cystitis.

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