Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis

Eleni Klinaki; Ioanna Argyri; Georgia Amountza; Gerina Ioannidou; Despoina Maritsi; Anastasia Garoufi; George Vartzelis

doi:10.1155/2019/7249237

Case Reports in Pediatrics (Jan 2019)

Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis

Eleni Klinaki,
Ioanna Argyri,
Georgia Amountza,
Gerina Ioannidou,
Despoina Maritsi,
Anastasia Garoufi,
George Vartzelis

Affiliations

Eleni Klinaki: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
Ioanna Argyri: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
Georgia Amountza: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
Gerina Ioannidou: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
Despoina Maritsi: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
Anastasia Garoufi: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece
George Vartzelis: 2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece

DOI: https://doi.org/10.1155/2019/7249237
Journal volume & issue: Vol. 2019

Abstract

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A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnormalities. However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. Discontinuation of vigabatrin quickly improved her symptoms and reversed the EEG slowing. A high index of suspicion is required in order to diagnose vigabatrin-induced encephalopathy, especially as the underlying disorders of these patients can be erroneously considered the cause of the observed encephalopathy.

Published in Case Reports in Pediatrics

ISSN: 2090-6803 (Print); 2090-6811 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://onlinelibrary.wiley.com/journal/2920

About the journal