Guoji Yanke Zazhi (Feb 2018)
Efficacy of different treatment modalities and the influence on PEDF and VEGF in patients with neovascular glaucoma in high altitude area
Abstract
AIM: To observe the clinical efficacy of different treatment modalities and the influence on the levels of pigment epithelium-derived factor(PEDF)and vascular endothelial growth factor(VEGF)in patients with neovascular glaucoma(NVG)in high altitude area. METHODS: Ninety cases of patients(90 eyes)with NVG treated in our hospital were selected as the study objects, and they were divided into Group A and Group B according to different surgery methods, 45 cases in each groups. Group A was given Ex-press glaucoma drainage device implantation, and Group B was given trabeculectomy combined with cyclocryotherapy. We observed the clinical efficacy, intraocular pressure and visual acuity in the two groups, detected the PEDF and VEGF levels in the aqueous humor, and recorded the postoperative complications. RESULTS: The total effective rate of Group A was 91%, significantly higher than that of Group B 76%(PPPP>0.05). At 1wk after operation, the incidence of visual reduction in Group A was 7%, significantly lower than that in Group B 22%(PPPPPPCONCLUSION: Ex-press glaucoma drainage device implantation, trabeculectomy combined with cyclocryotherapy can both be used to treat patients with NVG in high altitude area. But the former can effectively maintain visual acuity, and improve PEDF and VEGF levels in aqueous humor, with fewer complications and more accurate curative effect.
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