Hematological Profiles and Clinical Outcome of COVID-19 Among Patients Admitted at Debre Markos Isolation and Treatment Center, 2020: A Prospective Cohort Study

Abstract

Aytenew Atnaf,1 Abtie Abebaw Shiferaw,1 Workineh Tamir,1 Yibeltal Akelew,1 Milkiyas Toru,1 Daniel Tarekegn,2 Bekalu Bewket,3 Alemayehu Reta1 1Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Public health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 3Department of Nursing, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Aytenew Atnaf, Department of Medical Laboratory Sciences, College of Health Sciences, Debre Markos University, P.O.Box 269,  Debre Markos, Ethiopia, Tel [phone], Email [email protected]: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is coronavirus isolated from SARS patients. As far as the researchers’ knowledge, there was paucity of studies conducted in Ethiopia, particularly in the study area. As immune protection is arisen from our blood cells, assessing their level will provide a clue for controlling the disease and monitoring the prognosis. This study will also provide additional information for clinical intervention and patient management.Purpose: This study aimed to investigate the hematological profile and clinical outcome of coronavirus disease-19 (COVID-19) among patients admitted to the Debre Markos Isolation and Treatment Center (DMITC).Material and Methods: A prospective cohort study was conducted among 136 COVID-19 adult patients at DMITC from January 1, 2020 to March 30, 2021. Data related to clinical, hematological profiles and socio-demographic factors were collected, entered into Epi data, and analyzed using STATA 14.2 software. Multivariable logistic regression was applied to determine the predictor variable and a p-value < 0.05 was considered significant.Results: Of 136 COVID-19 patients, 28.68% had died. The mean age of patients was 47.21± 1.29 years. The hematological profile of the patients revealed that 28% had abnormal leukocyte, 23% abnormal lymphocyte, 44.85% abnormal granulocyte, 22.06% abnormal monocyte, 30.15% abnormal RBC and 87% abnormal platelet counts. The prevalence of anemia was 13.24%.Conclusion: Leukocytosis (mainly granulocytosis and monocytosis) and lymphopenia, were the predominant abnormal findings of complete blood cell count (CBC) analysis of the patient’s blood. Most of the patients had abnormally low platelet counts. RBC count and hematocrit determination were the only significant predictors of death. The clinician could manage cases according to the hematological findings of the patients. Further experimental studies should be conducted to determine hematological parameter changes and the clinical outcome of the disease.Keywords: leukocytosis, hematological profile, COVID-19, clinical outcome, Debre Markos

Keywords

• leukocytosis
• hematological profile
• covid-19
• clinical outcome
• debre markos