Protein-directed ribosomal frameshifting temporally regulates gene expression

Sawsan Napthine; Roger Ling; Leanne K. Finch; Joshua D. Jones; Susanne Bell; Ian Brierley; Andrew E. Firth

doi:10.1038/ncomms15582

Nature Communications (Jun 2017)

Protein-directed ribosomal frameshifting temporally regulates gene expression

Sawsan Napthine,
Roger Ling,
Leanne K. Finch,
Joshua D. Jones,
Susanne Bell,
Ian Brierley,
Andrew E. Firth

Affiliations

Sawsan Napthine: Division of Virology, Department of Pathology, University of Cambridge
Roger Ling: Division of Virology, Department of Pathology, University of Cambridge
Leanne K. Finch: Division of Virology, Department of Pathology, University of Cambridge
Joshua D. Jones: Division of Virology, Department of Pathology, University of Cambridge
Susanne Bell: Division of Virology, Department of Pathology, University of Cambridge
Ian Brierley: Division of Virology, Department of Pathology, University of Cambridge
Andrew E. Firth: Division of Virology, Department of Pathology, University of Cambridge

DOI: https://doi.org/10.1038/ncomms15582
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Programmed −1 ribosomal frameshifting (−1 PRF) is a mechanism whereby specific signals within mRNAs direct ribosomes to shift into an alternative reading frame. Here the authors describe a mechanism of −1 PRF that is temporally regulated by a viral protein over the course of the virus replicative cycle.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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