Overview of RNA interference therapeutics

Abstract

Since the term RNA interference (RNAi) was coined in 1998, much knowledge about RNAi has accumulated. Presently,RNAi is known as a power tool for studying gene function as well as a potential therapeutic molecular technique for a widerange of disorders. This review discusses potential problem areas such as off-target effects, in vivo delivery and RNAisaturation, and also indicates solutions including the current stage of RNAi therapeutics.

Keywords

• RNA inference
• siRNA
• off-target effects
• delivery
• RNAi therapeutics