Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

Lizhe Zhu; Hanlun Jiang; Siqin Cao; Ilona Christy Unarta; Xin Gao; Xuhui Huang

doi:10.1038/s42003-021-02822-7

Communications Biology (Nov 2021)

Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

Lizhe Zhu,
Hanlun Jiang,
Siqin Cao,
Ilona Christy Unarta,
Xin Gao,
Xuhui Huang

Affiliations

Lizhe Zhu: Warshel Institute for Computational Biology, School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen)
Hanlun Jiang: Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology
Siqin Cao: Department of Chemistry, The Hong Kong University of Science and Technology
Ilona Christy Unarta: Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology
Xin Gao: Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)
Xuhui Huang: Department of Chemistry, The Hong Kong University of Science and Technology

DOI: https://doi.org/10.1038/s42003-021-02822-7
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition by Argonaute.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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