Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma

Abstract

Objective To investigate the clinical pathological significance of tumor budding in T1 stage esophageal squamous cell carcinoma. Methods Tumor budding was searched for in the resected tissues of T1 stage esophageal squamous cell carcinoma(ESCC), and the relation between tumor budding and endoscopic classification, degree of malignancy in T1 ESCC were analyzed. Results The detection rate of tumor budding was significantly improved after EGFR labeling(P < 0.05). The detection rate of tumor budding in T1b ESCC was significantly higher than that of T1a SCC(P < 0.05). The detection rate of tumor budding in the cases with lymph node metastasis was significantly higher than that without lymph node metastasis(P < 0.05). The detection rate of tumor budding in stage ⅡB ESCC was significantly higher than those with stageⅠB(P < 0.05). Conclusion The detection rate of tumor budding in T1 ESCC is relatively high. The detection rates of tumor budding is improved by EGFR immunohistochemistrical labeling. The occurrence of tumor budding in T1 ESCC indicates more tumor aggression.

Keywords

• tumor budding
• esophageal squamous cell carcinoma
• endoscopic classification
• egfr