Nature Communications (Jun 2021)

Tumor suppressor p53 regulates intestinal type 2 immunity

  • Chun-Yuan Chang,
  • Jianming Wang,
  • Yuhan Zhao,
  • Juan Liu,
  • Xue Yang,
  • Xuetian Yue,
  • Huaying Wang,
  • Fan Zhou,
  • Juan M. Inclan-Rico,
  • John J. Ponessa,
  • Ping Xie,
  • Lanjing Zhang,
  • Mark C. Siracusa,
  • Zhaohui Feng,
  • Wenwei Hu

DOI
https://doi.org/10.1038/s41467-021-23587-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptional regulation of the Lrmp gene.