SPEN is required for Xist upregulation during initiation of X chromosome inactivation

Teresa Robert-Finestra; Beatrice F. Tan; Hegias Mira-Bontenbal; Erika Timmers; Cristina Gontan; Sarra Merzouk; Benedetto Daniele Giaimo; François Dossin; Wilfred F. J. van IJcken; John W. M. Martens; Tilman Borggrefe; Edith Heard; Joost Gribnau

doi:10.1038/s41467-021-27294-5

Nature Communications (Dec 2021)

SPEN is required for Xist upregulation during initiation of X chromosome inactivation

Teresa Robert-Finestra,
Beatrice F. Tan,
Hegias Mira-Bontenbal,
Erika Timmers,
Cristina Gontan,
Sarra Merzouk,
Benedetto Daniele Giaimo,
François Dossin,
Wilfred F. J. van IJcken,
John W. M. Martens,
Tilman Borggrefe,
Edith Heard,
Joost Gribnau

Affiliations

Teresa Robert-Finestra: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Beatrice F. Tan: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Hegias Mira-Bontenbal: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Erika Timmers: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Cristina Gontan: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Sarra Merzouk: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute
Benedetto Daniele Giaimo: Institute of Biochemistry, University of Giessen
François Dossin: European Molecular Biology Laboratory, Director’s Research
Wilfred F. J. van IJcken: Center for Biomics, Erasmus University Medical Center
John W. M. Martens: Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center
Tilman Borggrefe: Institute of Biochemistry, University of Giessen
Edith Heard: European Molecular Biology Laboratory, Director’s Research
Joost Gribnau: Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute

DOI: https://doi.org/10.1038/s41467-021-27294-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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