Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions

Paul S. Kwon; Shirley Xu; Hanseul Oh; Seok-Joon Kwon; Andre L. Rodrigues; Maisha Feroz; Keith Fraser; Peng He; Fuming Zhang; Jung Joo Hong; Robert J. Linhardt; Jonathan S. Dordick

doi:10.1038/s42003-023-04789-z

Communications Biology (Apr 2023)

Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions

Paul S. Kwon,
Shirley Xu,
Hanseul Oh,
Seok-Joon Kwon,
Andre L. Rodrigues,
Maisha Feroz,
Keith Fraser,
Peng He,
Fuming Zhang,
Jung Joo Hong,
Robert J. Linhardt,
Jonathan S. Dordick

Affiliations

Paul S. Kwon: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute
Shirley Xu: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Hanseul Oh: National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology
Seok-Joon Kwon: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Andre L. Rodrigues: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Maisha Feroz: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Keith Fraser: Department of Biological Sciences, Rensselaer Polytechnic Institute
Peng He: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute
Fuming Zhang: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Jung Joo Hong: National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology
Robert J. Linhardt: Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute
Jonathan S. Dordick: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute

DOI: https://doi.org/10.1038/s42003-023-04789-z
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 8

Abstract

Read online

Suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on SARS-CoV-2 RBDs with preferential binding for Omicron RBD and inhibition of infection by the Omicron variant in vitro.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal