Nature Communications (Jan 2022)
Reversing insecticide resistance with allelic-drive in Drosophila melanogaster
Abstract
Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.