Frontiers in Pharmacology (Oct 2018)
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy
- Jinti Lin,
- Jinti Lin,
- Jinti Lin,
- Renjin Lin,
- Renjin Lin,
- Renjin Lin,
- Shihen Li,
- Shihen Li,
- Shihen Li,
- Hongqiang Wu,
- Hongqiang Wu,
- Hongqiang Wu,
- Jian Ding,
- Jian Ding,
- Jian Ding,
- Guangheng Xiang,
- Guangheng Xiang,
- Guangheng Xiang,
- Shi Li,
- Shi Li,
- Shi Li,
- Yiru Wang,
- Dingsheng Lin,
- Dingsheng Lin,
- Dingsheng Lin,
- Weiyang Gao,
- Weiyang Gao,
- Weiyang Gao,
- Jianzhong Kong,
- Jianzhong Kong,
- Jianzhong Kong,
- Huazi Xu,
- Huazi Xu,
- Huazi Xu,
- Kailiang Zhou,
- Kailiang Zhou,
- Kailiang Zhou
Affiliations
- Jinti Lin
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Jinti Lin
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Jinti Lin
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Renjin Lin
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Renjin Lin
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Renjin Lin
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Shihen Li
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Shihen Li
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Shihen Li
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Hongqiang Wu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Hongqiang Wu
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Hongqiang Wu
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Jian Ding
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Jian Ding
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Jian Ding
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Guangheng Xiang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Guangheng Xiang
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Guangheng Xiang
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Shi Li
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Shi Li
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Shi Li
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Yiru Wang
- Department of Neurology, Wenzhou Traditional Chinese Medicine Hospital, Wenzhou, China
- Dingsheng Lin
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Dingsheng Lin
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Dingsheng Lin
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Weiyang Gao
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Weiyang Gao
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Weiyang Gao
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Jianzhong Kong
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Jianzhong Kong
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Jianzhong Kong
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Huazi Xu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Huazi Xu
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Huazi Xu
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Kailiang Zhou
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Kailiang Zhou
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Kailiang Zhou
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- DOI
- https://doi.org/10.3389/fphar.2018.01178
- Journal volume & issue
-
Vol. 9
Abstract
Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps.
Keywords
