Establishment of a Poliovirus Containment Program and Containment Certification Process for Poliovirus-Essential Facilities, United States 2017–2022

Christy Ottendorfer; Bryan Shelby; Cecelia A. Sanders; Anna Llewellyn; Christy Myrick; Christye Brown; Suganthi Suppiah; Kortney Gustin; Lia Haynes Smith

doi:10.3390/pathogens13020116

Pathogens (Jan 2024)

Establishment of a Poliovirus Containment Program and Containment Certification Process for Poliovirus-Essential Facilities, United States 2017–2022

Christy Ottendorfer,
Bryan Shelby,
Cecelia A. Sanders,
Anna Llewellyn,
Christy Myrick,
Christye Brown,
Suganthi Suppiah,
Kortney Gustin,
Lia Haynes Smith

Affiliations

Christy Ottendorfer: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA
Bryan Shelby: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA
Cecelia A. Sanders: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA
Anna Llewellyn: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA 30329, USA
Christy Myrick: Centers for Disease Control and Prevention, Office of Laboratory Science and Safety, Atlanta, GA 30329, USA
Christye Brown: Morehouse School of Medicine, Atlanta, GA 30310, USA
Suganthi Suppiah: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA
Kortney Gustin: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA
Lia Haynes Smith: Centers for Disease Control and Prevention, Office of Readiness and Response, U.S. National Authority for Containment of Poliovirus, Atlanta, GA 30329, USA

DOI: https://doi.org/10.3390/pathogens13020116
Journal volume & issue: Vol. 13, no. 2
p. 116

Abstract

Read online

Upon declaration of poliovirus (PV) type 2 eradication in 2015, the World Health Organization (WHO) published PV containment requirements in the Global Action Plan III (GAPIII) for mitigating the risk of a facility-associated release post eradication. In 2018, the 71st World Health Assembly resolution urged member states retaining PV to appoint a National Authority for Containment (NAC), reduce the number of PV facilities, and submit applications for containment certification. The United States (US) NAC was established in 2018 for containment oversight, and two paths to WHO GAPIII containment certification were developed. Facilities retaining PV were identified through national poliovirus containment surveys. The US NAC conducted 27 site visits at 18 facilities (20 laboratories: A/BSL-2 (65%), A/BSL-3 (20%), and storage-only (15%)) to verify the implementation of US NAC’s preliminary containment measures. The NAC identified areas for improvement in seven categories: primary containment, decontamination, hand hygiene, security, emergency response, training, and immunization practices. Sixteen facility applications were endorsed to pursue poliovirus-essential facility (PEF) certification, whereas four facilities opted to withdraw during the containment certification process. The US made noteworthy progress in PV containment to enhance biosafety and biosecurity practices at US PV facilities to safeguard the polio eradication effort.

Published in Pathogens

ISSN: 2076-0817 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/pathogens

About the journal

Abstract

Keywords