Molecules
(Dec 2018)
HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
Guangkai Yao,
Zhi-Xiang Zhang,
Cheng-Bei Zhang,
Han-Hong Xu,
Ri-Yuan Tang
Affiliations
Guangkai Yao
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
Zhi-Xiang Zhang
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
Cheng-Bei Zhang
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
Han-Hong Xu
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
Ri-Yuan Tang
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China
DOI
https://doi.org/10.3390/molecules23123317
Journal volume & issue
Vol. 23,
no. 12
Abstract
Read online
1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.
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