Non thrombotic antiphospholipid syndrome: neurologic and hematologic inflammatory manifestations

Abstract

Antiphospholipid syndrome (APS) is an entity defined for the presence of antiphospholipid antibodies and events such as recurrent fetal loss and arterial or ve-nous thrombosis. APS diagnosis is made through clas-sification criteria, including laboratory criteria and clinical manifestations (most of them being throm-botic manifestations). Nonetheless, there is a wide variety of non-thrombotic manifestations of APS, which are not included in classification criteria. These “non-criteria” manifestations are important for decision making, based on their frequency or clinical relevan-ce. Among them, some domains stand out: the hematologic domain, being thrombocytopenia the main manifestation; and the neurological domain with different manifestations such as migraine, epilepsy, dementia and severe manifestations, such as chorea and myelitis. Therefore, in the present article, information concerning two of the most common “noncriteria” domains (neurological and hematological) of APS is reviewed.

Keywords

• antiphospholipid syndrome
• chorea
• dementia
• epilepsy
• headache
• myeliti
• thrombocytopenia