Efficacy of Prothrombin Complex Concentrate versus Fresh Frozen Plasma in Patients with Bleeding in the Emergency Department

Abstract

Aim:It is important to determine which of the treatment options applied in the emergency department is more effective and usable in coagulation pathologies. In this study, we aimed to evaluate the efficacy and safety of fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC), which are used in the treatment of high hemostasis parameters in the emergency department.Methods:This retrospective study included 103 patients who were admitted to the emergency department between January 2019 and December 2020. All data were obtained from the hospital automation system. While the patients were divided into two groups (FFP-PCC) according to the treatment option they received, they were also divided into three groups (DED-RSH-ISH) according to hospitalization status. With this data, treatment efficacy and outcomes were analyzed.Results:The mean age of 103 patients was 67.31±13.17 years, with 58 (56%) females and 45 (44%) males. 51 (49.5%) of the cases received FFP and 52 (50.5%) PCC treatment. While the international normalized ratio (INR)1 value before the treatment was 7.56±4.09 and 2.42±1.01 after the treatment in the FFP group, the INR1 value was 10.12±5.18 and INR2 1.95±0.71 in the PCC group. The percentage of INR decrease was 60.28±19.76 (%) in the FFP group, and 73.41±17.42 (%) in the PCC group (p=0.001). In receiver operating characteristic curve analysis, the sensitivity and specificity of FFP and PCC decreased significantly in INR%.Conclusion:FFP is preferable in this regard to FFP because it is easier to apply, has a faster effect, and provides better values in coagulation parameters.

Keywords

• emergency departments
• fresh frozen plasma
• hemostasis
• blood coagulation factors
• prothrombin complex concentrates