Hemostatic System and its Regulation in Disorders of Renal Function

Abstract

In various violations of kidney function, there is a change in the hemostatic system, which can manifest itself in the form of thrombosis or bleedings. In these processes, vascular endothelium, platelets, plasma proteins of clotting and anti-clotting systems are involved. For correction of hemostatic disorders in uremic patients, the antithrombotic therapy (anticoagulants, antiplatelets agents) is used in hypercoagulation, and desmopressin, cryoprecipitate, conjugated estrogens, recombinant human erythropoietin, transfusions of red blood cells — in bleedings. The algorithm for the study of hemostatic system is recommended, in its use it is possible to prescribe adequate therapy depending on the thromboembolic or hemorrhagic complications.

Keywords

• hemostasis
• impaired renal function
• platelets
• coagulation cascade
• anticoagulants
• antiplatelet agents
• uremic bleeding and antithrombotic therapy
• antithrombotic therapy in uremic patients
• hemostasis system research algorithm