Nature Communications (Jan 2021)

Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC

  • Kendal G. Cooper,
  • Audrey Chong,
  • Laszlo Kari,
  • Brendan Jeffrey,
  • Tregei Starr,
  • Craig Martens,
  • Molly McClurg,
  • Victoria R. Posada,
  • Richard C. Laughlin,
  • Canaan Whitfield-Cargile,
  • L. Garry Adams,
  • Laura K. Bryan,
  • Sara V. Little,
  • Mary Krath,
  • Sara D. Lawhon,
  • Olivia Steele-Mortimer

DOI
https://doi.org/10.1038/s41467-020-20558-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Protein HilD of Salmonella Typhimurium coordinates motility and host cell invasion by upregulating flagellar genes and a secretion system. Here, Cooper et al. show that HilD also modulates swimming behaviour by upregulating a subunit of the chemotactic receptor array, and this is important for invasion of epithelial cells.