Morphometric development of the human fetal cerebellum during the early second trimester
Feifei Xu,
Xinting Ge,
Yonggang Shi,
Zhonghe Zhang,
Yuchun Tang,
Xiangtao Lin,
Gaojun Teng,
Fengchao Zang,
Nuonan Gao,
Haihong Liu,
Arthur W. Toga,
Shuwei Liu
Affiliations
Feifei Xu
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA
Xinting Ge
Department of Medical Imaging, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China; Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA
Yonggang Shi
Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA
Zhonghe Zhang
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021, Jinan, Shandong, China
Yuchun Tang
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China
Xiangtao Lin
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021, Jinan, Shandong, China
Gaojun Teng
Department of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009, Nanjing, Jiangsu, China
Fengchao Zang
Department of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009, Nanjing, Jiangsu, China
Nuonan Gao
Nanjing First Hospital, Affiliated to Nanjing Medical University, 210006, Nanjing, Jiangsu, China
Haihong Liu
Department of Medical Imaging, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China
Arthur W. Toga
Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA
Shuwei Liu
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Corresponding author.
The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain.
