CD36 maintains the gastric mucosa and associates with gastric disease

Miriam Jacome-Sosa; Zhi-Feng Miao; Vivek S. Peche; Edward F. Morris; Ramkumar Narendran; Kathryn M. Pietka; Dmitri Samovski; Hei-Yong G. Lo; Terri Pietka; Andrea Varro; Latisha Love-Gregory; James R. Goldenring; Ondrej Kuda; Eric R. Gamazon; Jason C. Mills; Nada A. Abumrad

doi:10.1038/s42003-021-02765-z

Communications Biology (Nov 2021)

CD36 maintains the gastric mucosa and associates with gastric disease

Miriam Jacome-Sosa,
Zhi-Feng Miao,
Vivek S. Peche,
Edward F. Morris,
Ramkumar Narendran,
Kathryn M. Pietka,
Dmitri Samovski,
Hei-Yong G. Lo,
Terri Pietka,
Andrea Varro,
Latisha Love-Gregory,
James R. Goldenring,
Ondrej Kuda,
Eric R. Gamazon,
Jason C. Mills,
Nada A. Abumrad

Affiliations

Miriam Jacome-Sosa: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Zhi-Feng Miao: Department of Surgical Oncology, Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, First Hospital of China Medical University
Vivek S. Peche: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Edward F. Morris: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Ramkumar Narendran: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Kathryn M. Pietka: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Dmitri Samovski: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Hei-Yong G. Lo: Division of Gastroenterology, Department of Medicine, Washington University School of Medicine
Terri Pietka: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Andrea Varro: Institute of Translational Medicine, University of Liverpool
Latisha Love-Gregory: Department of Pathology & Immunology, Washington University School of Medicine
James R. Goldenring: Departments of Surgery and Cell and Developmental Biology, Vanderbilt University Medical Center and VA Medical Center
Ondrej Kuda: Institute of Physiology, Czech Academy of Sciences, Videnska 1083
Eric R. Gamazon: Division of Genetic Medicine, Vanderbilt University Medical Center
Jason C. Mills: Gastroenterology & Hepatology Section, Departments of Medicine and of Molecular and Cellular Biology, Baylor College of Medicine
Nada A. Abumrad: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02765-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Jacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial cell renewal and progenitor cell differentiation, due to reduced fatty acid delivery and altered lipid metabolism, and find associations between low CD36 expression and gastric diseases.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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